ESR 13

Diffuse optical monitoring and prediction of neoadjuvant chemotherapy for personalized breast cancer management
Host institution/company
Ospedale San Raffaele (Italy)
Supervisors
Non-Academic
Dr. Pietro Panizza, Breast Imaging Unit, Ospedale San Raffaele, Milano, Italy

Academic
Prof. Paola Taroni, Department of Physics, Politecnico di Milano.
Type of contract
36-months full-time research grant within the PHAST-ETN project
Brief description of the project
Specific instructions for the local institution
No later than October 31, 2020, the successful candidate shall have obtained:
- a Laurea Magistrale in Italy with minimum marks of 95/110 or 86/100 (or equivalent qualifications, with minimum marks as specified on page 12 at this link); 
- a certification of the knowledge of English with minimum level as specified at: www.dottorato.polimi.it

Brief description of the project 
The research group at Politecnico di Milano has long experience in time domain Diffuse Optical Imaging and Spectroscopy. Through the estimate of the optical properties (absorption and scattering), the technique allows one to obtain non-invasively diagnostically relevant information such as tissue composition (lipids, water and collagen concentrations), physiological parameters (blood volume and oxygenation), as well as information on the microscopic structure of tissue. 
The ESR project will focus on the application of diffuse optics to the management of breast cancer at large. Examples of uses that can be envisaged are the monitoring and prediction of neoadjuvant chemotherapy outcome (which presently no conventional medical diagnostic technique can offer), the improvement of the specificity of imaging for the diagnosis of breast cancer, and the estimate of cancer risk. The ESR will work on the development of innovative photonics devices and their application in clinical investigations, and on the development of novel methods for the analysis of optical data and on their use for diagnostic purposes.
Planned secondments at Politecnico di Milano (Italy), Horiba (France), ICFO (Spain).
Qualifications
Essential
Applicants should hold (or expect to attain no later than October 31, 2020), as a minimum an MSc (or equivalent degree) in Optical Engineering or Photonics, Bioengineering, Biotechnology, Computer Science, Physics, or related areas.
Knowledge and Experience
Essential
A demonstrated knowledge of at least two of the following subjects: biophotonics, optical sensing, spectroscopy, lasers, bioengineering, data analysis, statistics, control of instrumentation.

Desirable
Research experience in at least one of the above disciplines.
Skills and Competencies
Essential
Applicants whose first language is not English must submit evidence of competency in English, please see Politecnico di Milano language skills required to be enrolled in a PhD Course.
Evidence of interest, aptitude and research experience in the above disciplines.
Further information
Further information on the research program: Dr. Pietro Panizza (panizza.pietro@hsr.it) and Prof. Paola Taroni (paola.taroni@polimi.it).
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