Point-of-care Raman microspectroscopy for detecting tumour markers in body liquids
Host institution/company
Friedrich-Schiller University Jena (Germany)
Prof. Dr. Juergen Popp and apl. Prof. Michael Schmitt, Chair for Physical Chemistry (Biophotonics), Institute of Physical Chemistry, Friedrich-Schiller

University Jena. - Industrial
Dr. Sebastien Legendre, HORIBA Jobin Yvon S.A.S. (France)
Type of contract
36-months full-time research grant within the PHAST-ETN project.
Brief description of the project
The group at the Friedrich-Schiller University has long-lasting expertise in the development and application of linear and non-linear Raman approaches for medical diagnosis and therapy. The Raman approaches are adapted according to the needs of pathology, oncology, and infection/ sepsis, and have been tested in realistic clinical scenarios.

The ESR project will develop spectral acquisition protocols for Raman spectroscopic analysis of body fluids. In this context it is very important to develop standardized sampling approaches leading to reproducible Raman measurements of body liquids.
The researched spectral acquisition protocols will be implemented in an automated point-of-care measuring protocol. Further objectives are the development of custom-made chemometric data evaluation protocols, development of SERS labels, i.e. of specially functionalized nanoparticles as selective plasmonic tumour markers.
Achieving these objectives will provide standard operating procedures (SOPs) for the Raman spectroscopic point-of-care analysis of body liquids to detect tumour markers leading to an improved personalized treatment of patients.

Planned secondments at Politecnico di Torino (Italy), Università degli Studi di Parma (Italy) and HORIBA Jobin Yvon S.A.S. (France)
Applicants should hold or expect to attain, as a minimum an MSc in Chemistry, Physics, Photonics or related area.
Knowledge and Experience
A demonstrated knowledge of at least two of the following: laser spectroscopy with focus on vibrational spectroscopy and application in biomedicine, photonics, optical sensing, statistical data analysis or wet chemistry experience.

Research project carried out in at least one of the above disciplines.
Skills and Competencies
- Applicants whose first language is not English must submit evidence of competency in English.
- Evidence of interest, aptitude and research experience in the above disciplines.
Further information
For any informal queries, please contact apl. Prof. Michael Schmitt by email at
Information sheet

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