ESR 2

Point-of-care Raman microspectroscopy for detecting tumour markers in body liquids
Host institution/company
Friedrich-Schiller University Jena (Germany)
Supervisors
Academic
Prof. Dr. Juergen Popp and apl. Prof. Michael Schmitt, Chair for Physical Chemistry (Biophotonics), Institute of Physical Chemistry, Friedrich-Schiller

University Jena. - Industrial
Dr. Sebastien Legendre, HORIBA Jobin Yvon S.A.S. (France)
Type of contract
36-months full-time research grant within the PHAST-ETN project.
Brief description of the project
The group at the Friedrich-Schiller University has long-lasting expertise in the development and application of linear and non-linear Raman approaches for medical diagnosis and therapy. The Raman approaches are adapted according to the needs of pathology, oncology, and infection/ sepsis, and have been tested in realistic clinical scenarios.

The ESR project will develop spectral acquisition protocols for Raman spectroscopic analysis of body fluids. In this context it is very important to develop standardized sampling approaches leading to reproducible Raman measurements of body liquids.
The researched spectral acquisition protocols will be implemented in an automated point-of-care measuring protocol. Further objectives are the development of custom-made chemometric data evaluation protocols, development of SERS labels, i.e. of specially functionalized nanoparticles as selective plasmonic tumour markers.
Achieving these objectives will provide standard operating procedures (SOPs) for the Raman spectroscopic point-of-care analysis of body liquids to detect tumour markers leading to an improved personalized treatment of patients.

Planned secondments at Politecnico di Torino (Italy), Università degli Studi di Parma (Italy) and HORIBA Jobin Yvon S.A.S. (France)
Qualifications
Essential 
Applicants should hold or expect to attain, as a minimum an MSc in Chemistry, Physics, Photonics or related area.
Knowledge and Experience
Essential 
A demonstrated knowledge of at least two of the following: laser spectroscopy with focus on vibrational spectroscopy and application in biomedicine, photonics, optical sensing, statistical data analysis or wet chemistry experience.

Desirable
Research project carried out in at least one of the above disciplines.
Skills and Competencies
Essential 
- Applicants whose first language is not English must submit evidence of competency in English.
- Evidence of interest, aptitude and research experience in the above disciplines.
Further information
For any informal queries, please contact apl. Prof. Michael Schmitt by email at m.schmitt@uni-jena.de.
Information sheet

Other ESR Positions

ESR 1
Integrated liquid biopsy for cancer diagnostics via genomic markers detection
ESR 5
Hybrid diffuse optical monitoring and theranostics with blood flow and oxygen metabolism biomarkers on pre-clinical models
ESR 6
Time-gated diffuse optical spectroscopy for deep tissue diagnostics
ESR 10
Multimodal intraoperative handheld forward-imaging probe
ESR 13
Diffuse optical monitoring and prediction of neoadjuvant chemotherapy for personalized breast cancer management
ESR 14
Tissue identification for surgical guidance using biophotonics
ESR 15
Micro-camera for hyperspectral imaging for in-vivo probing

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