Multimodal nonlinear imaging for clinical diagnosis in combination with laser tissue ablation for selective tissue removal
Host institution/company
Leibniz-Institute of Photonic Technology Jena (Germany)
Prof. Dr. Juergen Popp, Scientific director Leibniz-Institute of Photonic Technology (Leibniz-IPHT) and head of research department Spectroscopy / Imaging at Leibniz-IPHT.

Dr. Bernhard Messerschmidt, Grintech GmbH (Germany)
Type of contract
36-months full-time research grant within the PHAST-ETN project
Brief description of the project
The spectroscopy and imaging group at the Leibniz-Institute of Photonic Technology focuses on researching innovative optical/photonic methods for multiscale spectroscopy and multimodal imaging for clinical diagnostics and therapy.
The ESR project will work on the development of specially tailored analysis routines for a timely evaluation of the multimodal images together with the adjustment of an existing multimodal microscope combining the modalities CARS (coherent anti-Stokes Raman scattering), TPEF (two-photon excited autofluorescence) and SHG (second harmonic generation) towards a multimodal surgery microscope.
In this context the development of a miniaturized rigid free-beam optical probe, which can be attached to the aforementioned existing multimodal microscope (in cooperation with ESR8) takes center stage.
Furthermore, the design and development of innovative fibre optical probes for multimodal endoscopy allowing for the simultaneous implementation of several spectroscopic modalities (e.g. CARS, SHG and TPEF) will be a further objective of the ESR. Finally, it is planned to combine multimodal imaging and laser tissue ablation.
Achieving these objectives will provide the basis for using multimodal imaging as intraoperative approach to detect tumour surgical margins and the selective removal of tumour by laser tissue ablation.

Planned secondments at Grintech GmbH Jena (Germany), Medical University Vienna (Austria), Carl Zeiss Meditec AG Jena (Germany) and Jena University Hospital (Germany).
Applicants should hold or expect to attain, as a minimum an MSc in Physics, Chemistry, Optics/Photonics or related area.
Knowledge and Experience
A demonstrated knowledge of at least two of the following: optical spectroscopy / microscopy and their application in biomedicine, photonics / optics, laser physics, optical design, nonlinear optics, electronics, technical programming language (Labview, or R), image analysis.

Research project carried out in at least one of the above disciplines.
Skills and Competencies
- Applicants whose first language is not English must submit evidence of competency in English,
- Evidence of interest, aptitude and research experience in the above disciplines.
Further information
For any informal queries, please contact Prof. Juergen Popp by email at
Information sheet

Other ESR Positions

Integrated liquid biopsy for cancer diagnostics via genomic markers detection
Point-of-care Raman microspectroscopy for detecting tumour markers in body liquids
Hybrid diffuse optical monitoring and theranostics with blood flow and oxygen metabolism biomarkers on pre-clinical models
Time-gated diffuse optical spectroscopy for deep tissue diagnostics
ESR 10
Multimodal intraoperative handheld forward-imaging probe
ESR 13
Diffuse optical monitoring and prediction of neoadjuvant chemotherapy for personalized breast cancer management
ESR 14
Tissue identification for surgical guidance using biophotonics
ESR 15
Micro-camera for hyperspectral imaging for in-vivo probing

Stay in touch

subscribe to our newsletter service